Avoid sapwood of red oak as, with its sugars, it will attract insects and decay fungi. Keep it as dry as possible...good roof overhang and no shrubs or trees close to the walls to restrict drying breezes. Rain gutters will also help. A water repellant coating is awesome.
Nailing is important so that the wood can move without loosening the nail or screw. Wood movement means the outer surface can have some open joints unless special construction, such as board and batten, is used. Some pieces of oak from today's smaller diameter trees will warp. Today's wood also is not as decay resistant as in the past. So, old barns do not accurately predict the behavior of today's barns made with today's wood.
Woodpeckers, carpenter bees, termites, powder post beetles, etc. are risks, so keep you eye on the wood and fix the any issues promptly to avoid severe damage...it may not happen, but often it does.
Note that in most of the South, the average relative humidity is close to 65% to 75% RH which is 12% to 15% EMC. Our bodies say it is more humid, but our bodies do not estimate humidity well. What large city are you close too? You can look up the condition at
http://www.fpl.fs.fed.us/documnts/fplrn/fplrn268.pdf